Research use onlyNot for human consumption
Longevity & Energy
MOTS-C
Mitochondrial Health Peptide
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a mitochondrial-derived peptide (MDP) that plays a key role in cellular energy regulation, metabolic health, and stress resilience. Research suggests MOTS-C supports glucose metabolism, improves insulin sensitivity, and activates cellular pathways associated with metabolic and lifespan health.
Trusted Quality
Quick Facts
- Full Name: Mitochondrial Open Reading Frame of the 12S rRNA-C
- Category: Mitochondrial-Derived Peptide
- Molecular Weight: ~4.7 kDa
- Sequence Length: 16 amino acids
- Primary Focus: Metabolic health, mitochondrial function, insulin sensitivity
- Research Use: For research purposes only
Research Highlights
- Shown to improve insulin sensitivity and glucose metabolism in preclinical studies
- Activates AMPK, a key regulator of cellular energy balance
- Supports mitochondrial function and metabolic flexibility
- Associated with improved exercise capacity and reduced metabolic stress in animal models
- May influence healthy aging pathways and stress resistance at the cellular level
How MOTS-C Works
MOTS-C is a mitochondrial-derived peptide that functions as a metabolic regulator. It translocates to the nucleus and activates AMPK, helping cells adapt to metabolic stress, improve glucose uptake, and enhance mitochondrial efficiency. By supporting cellular energy balance and metabolic homeostasis, MOTS-C may promote resilience, metabolic health, and healthy aging.
Protocol Tips
- Common research protocols may use divided weekly dosing
- Often administered 2–3 times per week
- Can be used alone or in combination with other metabolic or longevity-focused peptides
- Subcutaneous administration is most common in research settings
- Maintain consistency and pair with a healthy lifestyle for best outcomes in research models
Cycle Guidance
- Research protocols typically utilize 8–16 week cycles, depending on the study model and goals
- Some research suggests benefits may be sustained with periodic use
- Optimal timing and duration should be tailored to specific research objectives
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